Antimicrobial and immunomodulatory effects of curcumin in fish
Dear colleagues,
This week we have chosen an article that shows the powerful direct and indirect antimicrobial effect of curcumin on Nile tilapia.
There are several articles that demonstrate the effect of curcumin as an intestinal protector and antimicrobial agent. For example, in one of our latest publications, I showed you the positive effects against Vibrio in shrimps.
The effect appears to be related to the suppression of bacterial cell proliferation and the interruption of prokaryotic cell division, but there is another more interesting effect related to immunomodulation which, in our opinion, is the key to its powerful effect. This effect is probably related to the strong antioxidant effect in both the gut and liver when absorbed, both key organs for the immune response. In this article, we see how curcumin is capable of increasing all immune parameters, innate immune response, and adaptive immune response in fish.
Desde nuestro punto de vista esto se debe a que la Curcumina permite un buen manejo de las moléculas oxidativas que está produciendo el sistema inmune innato para matar las bacterias, por lo que la autorregulación que produce la inmunosupresión para frenar un exceso de radicales libres no se activa y la consecuencia es una mayor actividad del sistema inmune innato y adaptativo.
In light of this study, we are not surprised by the positive effects it is also having on prawns, where the innate immune system is the only immune system and the hepatopancreas is a key organ.
Finally, we would like to remind you that curcumin levels must be kept under control because, although an excess of curcumin works very well as a direct antimicrobial agent, it is also a pro-oxidant and could negatively affect the intestinal tract, causing undesirable inflammation.
At Nutribiogenics, we have developed NBG EnteroShield, a potent source of curcumin protected with slow release to ensure the correct dose is always delivered to the intestine and bloodstream.
Disfruten del artículo.
